SPHYNX HCM DNA TEST

[pussiette]

Please Share Your Sphynx HCM DNA Results

Wondering how many Sphynx are testing POSITIVE/NEGATIVE? Dr. Meurs has indicated that she will not be able to share aggregate results of the DNA results for about a year (end of 2021.) Therefore, we have created this form to serve as an "unofficial way" to visualize what percentage of tested...

docs.google.com

@Sheldon13 @Bailey21 you can put your results in here too.

@admin @Catzzzmeow @Sheldon13 @Yoda mom can we please pin this thread? It is so important for the health of the breed.

 

[pussiette]

For those that have Donskoy thanks I received this information from the NCSU University.

Donskoy cats can also be susceptible to HCM. However, it should be noted that our genetic tests are very breed-specific. The genetic mutation identified in Sphynx cats is only known to be causative for HCM in full-bred Sphynx. We have not yet done research into Sphynx outcrosses such as Donskoy, so we do not know whether the Sphynx HCM mutation is also causative in Donskoy. You are still welcome to test a Donskoy cat if you please, but again, please know that we do not yet know the significance of this mutation in that breed.

@NakieCatMom

 

[Gary]

For those that have Donskoy thanks I received this information from the NCSU University.

Donskoy cats can also be susceptible to HCM. However, it should be noted that our genetic tests are very breed-specific. The genetic mutation identified in Sphynx cats is only known to be causative for HCM in full-bred Sphynx. We have not yet done research into Sphynx outcrosses such as Donskoy, so we do not know whether the Sphynx HCM mutation is also causative in Donskoy. You are still welcome to test a Donskoy cat if you please, but again, please know that we do not yet know the significance of this mutation in that breed.

@NakieCatMom

Will the test still be useful for an elf sphynx? (sphynx & American Curl) or it will only be relevant for pure-bred sphynx?

 

[pussiette]

@Gary great question on the Elf sphynx I will post a reply when the University responds to me. Thanks.

 

[pussiette]

@Gary here is the response from the University:

We are unsure whether the test would give viable results for any breed other than Sphynx. The test is very breed specific and is known to be casuitive in full-bred Sphynx, so for Elf Sphynx we do not know the effect that this genetic mutation has on that specific Sphynx breed at this time.

 

[Bailey21]

@Gary Finn is an elf straight sphynx "(his grandpa was an elf or elf bloodline I believe) and I got his results no problems. I would say if you want to test, then do it

 

[Gary]

@Gary Finn is an elf straight sphynx "(his grandpa was an elf or elf bloodline I believe) and I got his results no problems. I would say if you want to test, then do it

ok great ty. I'll probably just do it to see worst case doesn't really mean much I guess.

 

[pussiette]

@Gary Good luck doing it just make sure on the paperwork you are clear with the bloodlines (ie Elf) so they can provide you with the best analysis. Let us know how you go!

 

[Gary]

Thank you, just did the swab today. I hope I did it well enough as it was a bit hard to get the little dude held down and shove the swab in his mouth for 20-30 seconds like it said, he really didn't like it. I eventually just held it in my hands and he'd try and bite it and i'd roll it around the side of his mouth.

 

[Gary]

Thank you, just did the swab today. I hope I did it well enough as it was a bit hard to get the little dude held down and shove the swab in his mouth for 20-30 seconds like it said, he really didn't like it. I eventually just held it in my hands and he'd try and bite it and i'd roll it around the side of his mouth.

Yoda's test came back Negative for this genetic mutation for HCM

 

[Bailey21]

@Gary great news!

 

[Gary]

@Gary great news!

Yes happy start to the weekend!

 

[Catzzzmeow]

@Gary so happy for you

 

[guinnesspop]

Got my results in and unfortunately, Em is homozygous positive. Bit sad about it, but there's nothing for it; it is what it is. She already had a blood test to detect heart condition during the whole "WHY IS SHE SO SMALL" drama, so during her one year appointment I'll chat with the vet about making that a regular occurrence. Now I just need to decide whether or not I'll tell the breeder--and how, if so. I'm very interested to see if there's any longitudinal studies done as a result of this--like, how many homozygous positive cats develop HCM by one year, by five years, etc.

 

[Condo commando]

I don't think it's a given that she will develop the disease at all because they say this:
"At this time, we do not know if the risk of developing disease is higher in cats that are homozygous for the mutation than heterozygous."

Here is the link where I got that quote:

NC State College of Veterinary Medicine

We're a driving force in veterinary research and training.

cvm.ncsu.edu

 

[pussiette]

@Gary so glad for you.

@guinnesspop I am sorry they are not the results that you were hoping for. There are some homos that can live for a very long time there’s much they don’t know about it still. But it’s good that you got your results. And I would definitely give your results to the breeder so they can make better breeding decisions with this information. It means one or both parents have homozygous genes.

Regardless of results we need to keep HCM scanning our cats each year by a cardiologist.

I am so glad to see so many responsible owners do everything they possible can to find out how to stop this disease.

 

[guinnesspop]

We'll see how Em goes, then! I'll talk to her breeder sooner rather than later--she just had another litter, her first bambinos, and I'd be very surprised if she'd heard about the test. Breeding seems like such a pain. Staying on top of everything like this can't be easy.

 

[pussiette]

@guinnesspop so glad to hear you are across this.

 

[Leilalover]

I'm talking to a breeder who is breeding a het queen with a het stud, wouldn't this lead to a 1/4 chance of homo? And 2/4 het? Is this a red flag?

 

[ashleyc]

Hi I wanted to get this test done does anyone know how long it takes for results to come back? Is two days normal?

 

[babymeow]

I was thinking of doing the test, is it an accurate reflection of if your cat will get HCM?

 

[tuffysmommy]

Our results from NCSU came back in one day (!!!) last August. They warned it would take longer but it did not. The cost was still $40.
There is testing for other genetic diseases at UCDavis. This cost $140. The testing here is for genetic kidney, eye and muscle weakness genetic diseases.
Many people think I am in overkill about genetic testing but my personal take is that it gives me questions on conditions to ensure my vet and I keep an eye out for.

 

[Catzzzmeow]

I was thinking of doing the test, is it an accurate reflection of if your cat will get HCM?

Unfortunately not, but it is one more layer of awareness.

 

[Sheldon13]

It tests for some of the more common genetic causes of HCM, but not all. It took about a week to get results for Toly.


Sent from my iPhone using Tapatalk Pro

 

[babymeow]

Ok, thanks for the info. Does it affect health insurance and existing preconditions if something comes out positive?