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Recurring Skin Issues -- any advice?

sarmar

Lairian
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Jun 28, 2026
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Hi all,
I'm hoping to hear from anyone who's maybe dealt with something similar…

My cat Sam (Sphynx, turns 4 tomorrow!) has had skin issues on and off for over a year. We first noticed shallow scabs on his neck, then similar shallow/liquidy-then-hardening scabs on his back. We assumed it was from play or his sister Sally licking/grooming him, so honestly we didn't take it too seriously at first since he's furless and marks show up easily.

In March he developed an issue on one back paw. His vet thought it was a yeast issue, so we treated with MiconaHex+Triz wipes (and Douxo S3 Calm Mousse, used less consistently) but it improved without ever fully resolving. In May he developed more scabs on his back, and with the paw still not fully normal, we went back to the vet, who prescribed a Prednisolone suspension. That cleared everything up for a bit.

We decided to see a dermatologist a few weeks ago. He wasn’t currently having a flare, but cytology showed Malassezia (yeast), so the dermatologist gave us Douxo S3 Pyo shampoo. She did bloodwork for environmental allergies (we are still waiting on those results) and suggested we start a food allergy trial. We have not gotten far with this food trial because Sam refuses all the foods the vet says we need to use since they don’t have cross contamination.

A couple days ago, he started getting a few small scabs on his back and stomach, as well as another paw issue on his other back paw. The paw issue especially concerns me. It looks gruesome and he is licking/chewing it a lot more than usual. The dermatologist says it is feline atopic skin syndrome and Malassezia dermatitis (so pretty much an allergic condition with a yeast infection riding on top) with possible food allergy as well. She said to do 4 weeks oral fluconazole, Douxo S3 Pyo shampoo every 2 weeks, vinegar rinses, and a 3-month strict food trial (novel protein/hydrolyzed). Also waiting on environmental allergy bloodwork.

I am honestly a little suspicious of food allergies, given the only real paw flare was this past March and currently, so it feels like it could be seasonal/environmental. Maybe I am just dreading a food trial though! Haha

For anyone who's been through something similar with their Sphynx…
  • Did a food trial help? If so, do you have any tips for picky cats? And do you know of any brands of food that wouldn’t have cross contamination with chicken or fish?
  • Do you have any tips for managing recurring Malassezia/yeast on Sphynx skin? The vet recomended wiping him daily with a solution of 1 part vinegar to 20 parts water?
I very much appreciate any experience or advice anyone has. This has been a long, slow-building thing for him and I want to make sure I take good care of him so he is comfortable and so things don’t escalate!
 

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Catzzzmeow

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It is wonderful you are trying everything possible to get this figured out…kudos. I know you mentioned your want to try a food that does not have chicken/fish. We see that chicken seems to be the biggest culprit. You can google limited ingredient cat foods. They only have a couple of ingredients so less to rule out. I would start with one that the protein is not chicken. Hopefully the tests come back soon so you can see what exactly they are allergic to.

Also have you given thought that the issue might be the type of litter you are using? That can happen especially because the paws seem to be the biggest issue.
 

kauna

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Allergies are no fun I’ve been through it with my first Sphynx Agnes and my mastiff Otto. They were both on allergy serum injections. For Agnes the food that we gave was Royal canin Ultamino. It was new at the time we started it. Only comes in dry formula so for moisture we would make cereal (soak in water) she loved it. She had chronic yeast infections and it was mostly environmental. We also did medicated baths with duoxo.
Have you tried a ecollar to keep from licking the paws? Or tried a different litter?
Keep us posted!
 
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